Original Broadway Production:

The musical premiered on Broadway at the Gerald Schoenfeld Theatre (at the time known as the Plymouth Theatre) on April 28. Co-produced by Jerry Frankel and Jeffrey Richards, and directed by Robin Phillips, the original cast featured Robert Cuccioli as Jekyll and Hyde, Linda Eder as Lucy Harris, and Christiane Noll as Emma Carew, with Rob Evan originally cast as Cuccioli's alternate, performing the title roles at two performances per week (at matinees). The cast also featured George Robert Merritt as John Utterson, Barrie Ingham as Sir Danvers Carew and Martin Van Treuren as "Spider", all of whom played their respective roles throughout the entire run. Raymond Jaramillo McLeod was originally cast as Simon Stride. He was later replaced by Merwin Foard, who in turn, was replaced by Robert Jensen. Coleen Sexton was a swing in the company before becoming the final Lucy Harris. Sebastian Bach played the lead from June 15, 2000 to October 15, 2000. The musical played an almost-four-year run and became the longest-running show in the history of the Plymouth Theatre.

Broadway Revival:

The revival opened on Broadway at the Marquis Theatre on April 5, 2013 (previews), officially on April 18. Maroulis, Cox, and Wicks reprised their respective roles as Dr. Jekyll / Mr. Hyde, Lucy, and Emma.

Notable Jekyll and Hyde replacements include Anthony Warlow, Rob Evan, Kyle Dean Massey, Marti Pellow, Constantine Maroulis, Jack Wagner, and Sebastian Bach.

Other notable replacements include:

• Lucy Harris: Luba Mason, Coleen Sexton, Katherine Shindle (u/s)

• Emma Carew: Anastasia Barzee, Andrea Rivette, Kelli O'Hara (u/s), Rebecca Spencer (u/s)

• John Utterson: John Treacy Egan (u/s)

• Sir Danvers Carew: Peter Johl (u/s)

Music from Jekyll and Hyde have become standards in the American Musical Theater canon and are regularly used by figure skaters in their programs: